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  • Title: Clinical effect of a new liquid dentifrice containing triclosan/copolymer on existing plaque and gingivitis.
    Author: Triratana T, Rustogi KN, Volpe AR, DeVizio W, Petrone M, Giniger M.
    Journal: J Am Dent Assoc; 2002 Feb; 133(2):219-25. PubMed ID: 11868841.
    Abstract:
    BACKGROUND: Dentifrices traditionally have been formulated as pastes or gels. However, liquid varieties recently have become available The authors conducted a study to determine whether a fluoridated liquid product with added triclosan and a polyvinyl methyl ether/maleic acid, or PVM/MA, copolymer delivery system is efficacious for the control of supragingival plaque and gingivitis. METHODS: The authors conducted a six-month, double-blind, parallel, stratified clinical study in accordance with American Dental Association guidelines for the clinical evaluation of antiplaque/antigingivitis products. Subjects who qualified with a suitable amount of existing plaque and gingivitis were given one of two dentifrices: an "experimental" liquid dentifrice containing 0.3 percent triclosan, 2.0 percent PVM/MA copolymer and 0.243 percent sodium fluoride, or NaF, in a silica base; or a "placebo" dentifrice containing 0.243 percent NaF in a silica base. The authors collected subjects' plaque and gingival index scores at baseline, three months and six months. RESULTS: The results of the study indicate that the use of the experimental liquid dentifrice provided a significant reduction in existing levels of plaque and gingivitis as compared with the placebo standard dentifrice. At six months, the experimental group demonstrated a 34.9 percent reduction in plaque formation and a 25.7 percent reduction in gingivitis as compared with the placebo group (P < .001). CONCLUSIONS: When compared with the placebo, the experimental dentifrice had a significantly better ability to reduce plaque and gingivitis. When compared with results reported in the literature, this new form of dentifrice achieved results comparable in efficacy to those of traditional dentifrice pastes with matching active ingredients. CLINICAL IMPLICATIONS: This study confirms that a liquid dentifrice containing a triclosan/copolymer/NaF delivery system is efficacious in its ability to reduce existing plaque and gingivitis.
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