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  • Title: [Effect of regulatory peptides on the effect of cardiorespiratory synchronization in patients with heart diseases].
    Author: Osadchiĭ OE, Abushkevich VG, Kanorskiĭ SG, Pokrovskiĭ VM, Skibitskiĭ VV.
    Journal: Patol Fiziol Eksp Ter; 2001; (4):25-7. PubMed ID: 11871025.
    Abstract:
    A long-acting somatostatin analogue (sandostatin) and synthetic opioid dalargin were examined for the effect on the heart rhythm under the cardiorespiratory synchronization test in patients with heart disease. In high-frequency respiration synchronized with photostimulator flashes the patients exhibited cardiorespiratory synchronism when heart rate corresponds exactly to respiration rate. A spontaneous change of the respiration rate entailed corresponding changes in the heart rate. This allowed regulation of the heart rhythm. Intravenous injection of sandostatin or dalargin extended the range of the cardiorespiratory synchronization. The latter points to involvement of peptides in mechanisms of heart taking of the control signals coming from the central nervous system.
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