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  • Title: [Effect of plant melanin pigment on the clastogenic effects of chemical mutagens in mice].
    Author: Alekseeva TN, Durnev AD, Kulakova AV, Oreshchenko AV, Samusenok LV, Ogarkov BN, Seredenin SB.
    Journal: Eksp Klin Farmakol; 2001; 64(6):56-9. PubMed ID: 11871241.
    Abstract:
    The chromosome aberration assay in the bone marrow cells of C57BL/6 mice showed that melanin pigment (MP) in a dose range from 0.01 to 10 mg/kg does not influence the clastogenic effect of dioxidine (200 mg/kg, i.p.), while reducing the clastogenic effect of cyclophosphamide (20 mg/kg, i.p.) by a factor of 1.5-4 in various treatment regimes depending on the mutagen injection time.
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