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  • Title: New drug evaluation using exercise-induced bronchospasm.
    Author: Sprenkle AC, VanArsdel PP, Biermann CW.
    Journal: Pediatrics; 1975 Nov; 56(5 pt-2 suppl):937-9. PubMed ID: 1187285.
    Abstract:
    Exercise-induced asthma was used to demonstrate that a xanthone, a new orally active cromolyn-like drug, has significant activity in man. The effect of a single oral dose of 8 mg/kg was studied in a double-blind corss-over fashion at two and five hours after administration, with significant inhibition of post-exercise bronchospasm being seen at five hours. Further study seems indicated to determine optimal dosage and clinical effectiveness.
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