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  • Title: [The effects of escharectomy en masse during shock stage on the secretion of cytokines from macrophage in scalded rats].
    Author: Li Z, Huang Y, Yang Z.
    Journal: Zhonghua Shao Shang Za Zhi; 2000 Oct; 16(5):283-5. PubMed ID: 11876886.
    Abstract:
    OBJECTIVE: To explore the effects of the plasma from rats undergoing escharectomy en masse during shock stage on the secretion of TNFalpha, IL-6 and IL-8 by macrophage. METHODS: Rats inflicted by 30% III degree scald were employed as the model. Sixty-three rats were randomly divided into escharectomy (E) and scald (C) groups. The plasma contents of TNFalpha, IL-6 and IL-8 in rats in two groups were determined. The plasma from rats in two groups was respectively co-cultured with rat peritoneal macrophages for 6 hours and the TNFalpha, IL-6 and IL-8 in the supernatants of the culture were assayed. RESULTS: Plasma contents of TNFalpha, IL-6 and IL-8 were evidently increased in both E and C groups. But the contents of these cytokines in E group decrease and were much lower than those in C group at 12 postburn hour. The sera from two groups of rats could all stimulate the secretion of TNFalpha, IL-6 and IL -- 8 from peritoneal macrophages, but the serum from C group possessed stronger stimulating ability than that from E group. CONCLUSION: Escharectomy en masse during shock stage could weaken the ability of burn sera to induce the secretion of TNFalpha, IL-6 and IL-8 by macrophages. It was therefore beneficial to the prevention of postburn development of systemic inflammatory response syndrome.
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