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  • Title: [Anti-CD40 McAb induces CD40+ malignant B cell proliferation arrest and apoptosis].
    Author: Zhou Z, Shi Q, Wang J, Pan J, Zhang X.
    Journal: Zhonghua Xue Ye Xue Za Zhi; 2000 May; 21(5):237-9. PubMed ID: 11876986.
    Abstract:
    OBJECTIVE: To study the expression of CD(40) molecule and the biological effects mediated by CD(40) molecules on malignant B cells. METHODS: Agonistic anti-human CD(40) monoclonal antibody (5C11) was added to the cell culture system. Cell counting, PI staining, Annexin-V staining and flow cytometric analysis were used to study the biological effects of 5C11 on malignant B cell lines. RESULTS: 5C11 induced homotypic aggregation, proliferation arrest and apoptosis in the multiple myeloma cell line XG2 highly expressed CD(40). 5C11 induced B lymphoma cell line Daudi homotypic aggregation and proliferation arrest but no apoptosis. CONCLUSION: 5C11 can inhibit proliferation of malignant B cells by inducing apoptosis or arresting the cells at G(2)/M interphase.
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