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  • Title: [Detection of hypermethylation of p15 gene in patients with acute leukemia by polymerase chain reaction].
    Author: Chen F, Zeng X.
    Journal: Zhonghua Xue Ye Xue Za Zhi; 2000 May; 21(5):250-2. PubMed ID: 11876990.
    Abstract:
    OBJECTIVE: To explore the role of hypermethylation of p15 gene in the pathogenesis of acute leukemias. METHODS: DNA from 36 cases of acute leukemia were investigated using restriction enzyme digestion combined with polymerase chain reaction (PCR) technique. RESULTS: Hypermethylations of p15 gene were found in 22 (61.1%) patients, including 17 cases of acute non-lymphoblastic leukemia (ANLL) and 5 of acute lymphoblastic leukemia (ALL). ANLL patients exhibited p15 gene hypermethylations had higher WBC in peripheral blood (P < 0.05) and higher percentages of leukemia cells in bone marrow (P < 0.01). CONCLUSION: Inactivation of p15 gene due to hypermethylation may be involved in the pathogenesis of some acute leukemias.
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