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  • Title: [Evidence for TCR Vbeta clonal expansion T cells in a patient with cGVHD after unrelated donor BMT].
    Author: Du X, Li Y, Weng J, Lu Z, Su J, Lin W, Huang Z.
    Journal: Zhonghua Xue Ye Xue Za Zhi; 2000 Aug; 21(8):406-8. PubMed ID: 11877011.
    Abstract:
    OBJECTIVE: To investigate the distribution and clonal expansion of TCR Vbeta subfamily T cells in patients with cGVHD after unrelated donor bone marrow transplantation (BMT). METHODS: The CDR3 of 24 TCR Vbeta subfamily genes were amplified from peripheral mononuclear cells of a patient with cGVHD after unrelated BMT. RT-PCR was used for detection of the distribution of TCR Vbeta repertoire, and the PCR products were further analyzed by genescan technique for the CDR3 size, to evaluating clonality of the detectable TCR VbetaT cells. RESULTS: Only 8 Vbeta subfamily T cells could be identified in the patient, clonal expansion T cells could be found of Vbeta2, 3, 8 and 13 subfamilies. CONCLUSIONS: The skew distribution and clonal expansion of TCR Vbeta subfamily T cells could be found in the patient. It may relate to the initiation of cGVHD.
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