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  • Title: Mechanisms of resistance of Plasmodium falciparum to antimalarial drugs.
    Author: Hyde JE.
    Journal: Microbes Infect; 2002 Feb; 4(2):165-74. PubMed ID: 11880048.
    Abstract:
    Chemotherapy and chemoprophylaxis are the principal means of combating malaria parasite infections in the human host. In the last 75 years, since the introduction of synthetic antimalarials, only a small number of compounds have been found suitable for clinical usage, and this limited armoury is now greatly compromised by the spread of drug-resistant parasite strains. Our current knowledge of the molecular mechanisms underlying resistance in the lethal species Plasmodium falciparum is reviewed here.
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