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Title: Metabolism of glutethimide in the human. Author: Stillwell WG. Journal: Res Commun Chem Pathol Pharmacol; 1975 Sep; 12(1):25-41. PubMed ID: 1188186. Abstract: Gas chromatographic and gas chromatographic-mass spectrometric techniques were used to identify metabolites of glutethimide excreted in human urine. In this study three monohydroxy metabolites, a dihydrodiol and three dihydroxy metabolites were detected after ingestion of the drug. The results indicate that the phenyl ring of glutethimide is metabolized by the epoxide-dihydrodiol pathway in the human following chronic administration of the drug.[Abstract] [Full Text] [Related] [New Search]