These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Steroid-induced osteoporosis.
    Author: Sambrook PN.
    Journal: Ann Acad Med Singap; 2002 Jan; 31(1):48-53. PubMed ID: 11885496.
    Abstract:
    INTRODUCTION: Corticosteroids have major effects on calcium metabolism, leading to accelerated osteoporosis and fracture. METHODS: This review will attempt to summarise current knowledge about their effects in light of new information and important remaining questions, especially with respect to management of this common condition. RESULTS: Corticosteroids affect bone through multiple pathways, influencing both bone formation and bone resorption. Evidence from randomised trials suggests that postmenopausal women receiving corticosteroids are at greatest risk of rapid bone loss and consequent fracture and should be actively considered for prophylaxis. Based upon available evidence, the rank order of choice for prophylaxis would be a bisphosphonate followed by a vitamin D metabolite or hormone replacement. CONCLUSIONS: With early therapy, corticosteroid bone loss can be effectively prevented or reversed.
    [Abstract] [Full Text] [Related] [New Search]