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  • Title: Substituted indoloquinolines as new antifungal agents.
    Author: Ablordeppey SY, Fan P, Li S, Clark AM, Hufford CD.
    Journal: Bioorg Med Chem; 2002 May; 10(5):1337-46. PubMed ID: 11886797.
    Abstract:
    Cryptolepine (2) possesses desirable properties to serve as a lead in developing new antifungal agents. Using SAR techniques, several analogues of cryptolepine were designed to increase potency and to broaden the antifungal spectrum over several opportunistic microorganisms. A number of 2-substituted indoloquinolines have been synthesized and evaluated in antifungal screens and several have been shown to increase potency and expand the antifungal spectrum of cryptolepine. Comparison of MICs of a number of these analogues with standard antifungal agents, shows them to be comparable to Amphotericin B and Ketoconazole.
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