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  • Title: The amplitude and period of circannual cycles of body weight in golden-mantled ground squirrels with medial hypothalamic lesions.
    Author: Mrosovsky N.
    Journal: Brain Res; 1975 Nov 28; 99(1):97-116. PubMed ID: 1188988.
    Abstract:
    Golden-mantled ground squirrels, Citellus lateralis, were kept for several years in conditions of constant temperature and photoperiod. Control animals showed the expected circannual cycles of body weight, becoming fat in the autumn and thin in the spring. Animals with lesions in the ventromedial region of the hypothalamus also had circannual cycles of weight but in most animals the amplitude was increased. At one time of year the lesioned ground squirrels were grossly obese while often at other times their weight was close to that of control animals or their own preoperative weights. There were unusually early peaks in weight after the lesion in some animals and it is probable that a phase shift occurred. Observations on hibernation, food intake, transient weight gains and delayed weight gains following the lesions are also reported. Evidently during the winter phase of the annual cycle in these ground squirrels there exist mechanisms that lead not only to a loss of weight gained naturally before the time for hibernation but also to a temporary attenuation of additional obesity produced by ventromedial hypothalamic lesions.
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