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  • Title: [Particular profile of the zymodemes of Leishmania infantum causing visceral leishmaniasis in Tunisia].
    Author: Aoun K, Bouratbine A, Harrat Z, Belkaïd M, Bel Hadj Ali S.
    Journal: Bull Soc Pathol Exot; 2001 Dec; 94(5):375-7. PubMed ID: 11889934.
    Abstract:
    The isoenzymatic typing of 16 stocks of Leishmania, isolated from Tunisian visceral leishmaniasis (VL) cases, revealed that all strains belonged to Leishmania (L.) infantum species. Although zymodeme MON-1 was predictably the most frequent (9 cases), it came as a surprise that L. infantum MON-24 was responsible of about third of cases. This latter zymodeme, while previously reported in Tunisia, Algeria and Spain, was assumed to be a dermotropic and the few cases of VL that it caused occurred always in HIV infected patients. L. infantum MON-80, occasionally reported during both cutaneous and VL of immunocompetent infants was identified in 2 patients. This report confirms that in addition to the more common L. infantum MON-1, zymodeme MON-24 has a substantial role in generating VL in immunocompetent infants in Tunisia.
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