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  • Title: [Effect of dexamethasone on the formation of intestinal adhesions following postoperative radiotherapy].
    Author: Tanaka Y, Fujiwara T, Hayashi T, Ezumi R.
    Journal: Strahlentherapie; 1975 Jun; 149(6):608-20. PubMed ID: 1188994.
    Abstract:
    In order to study the effect of postoperative irradiation on intestinal adhesions and fibrosis and also determine the effects of DM on these processes, experiments were carried out on 76 rabbits and the following results were obtained: 1. When irradiation alone was conducted without any operative procedure, neither thickening of the intestinal canal and serosa nor adhesions occurred immediately after irradiation. 2. One week after postoperative irradiation, no effect of irradiation was noted on the intestine or the surgically induced adhesion. Several months later, however, collagenization of the site of the adhesion was seen. At this time, inflammation still persisted, so that further intensification of the adhesions remains a possibility. 3. DM definitely prevented intestinal adhesions secondary to surgery due to operation. It is also evident that this substance inhibits intestinal adhesions and collagenization induced by combined surgery and irradiation.
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