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  • Title: [Growth kinetics of transplantable mammary gland tumors in mice].
    Author: Ostrovskaia LA, Vermel' EM.
    Journal: Vopr Onkol; 1975; 21(10):77-88. PubMed ID: 1189355.
    Abstract:
    The function of: (see article), fits the tumors weight growth for all studied generations in both control and treated animals. Morphological studies show the transplantable tumors in A mice to lose their similarity to a spontaneous tumor--low differentiated adenocarcinoma. Meanwhile, the tumors in C3H mice have a high differentiation level which is typical for the original tumor. 1-nitroso-1-methylurea is very effective against the first generation of tumors in both strains of mice. The tumors response to the drug becomes weaker with further passages. 1-nitroso-1-methyl urea is superior to other nitrous derivatives when used in such tumor models as breast adenocarcinoma in C3H mice.
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