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  • Title: [Acute effect of lidoflazine on the electrocardiographic agitation discharge in atrial frequency stimulation (studies on patients with stress-induced coronary insufficiency)].
    Author: Lehmann HU, Beck OA, Hochrein H.
    Journal: Z Kardiol; 1975 May; 64(5):396-410. PubMed ID: 1189535.
    Abstract:
    Electrocardiographic alterations and onset of angina pectoris during an acute treatment period with lidoflazine -3 to 4 mg/kg b.w. by oral application- was investigated in 20 patients with latent coronary insufficiency under increasing heart rate condition by atrial pacing. Significant changes in the repolarisation phase mainly due to prolongation of the QTc-interval already appeared 90 to 120 min after oral administration. The onset of test-induced agina pectoris and ischaemic ST-segmental depression in the ECG were not influenced by lidoflazine. Exceeding a rate of 140 min-1 produced a delay of atrioventricular conduction time under drug influence whereas significant changes of intraventricular conduction did not appear. Under frequent heart rates bundle branch block developed in a few individuals that might be drug-induced. In addition, there were some signs of digitalis-potentiation by lidoflazine.
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