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  • Title: [Postradiation recovery of hematopoiesis in mice affected by Neogen (IEW)].
    Author: Semenets TN, Semina OV, Deĭgin VI, Vinogradova IuE, Maliutina IaV, Budagova KR, Shinkarkina AP, Poverennyĭ AM.
    Journal: Radiats Biol Radioecol; 2002; 42(1):70-4. PubMed ID: 11898635.
    Abstract:
    The effect of the synthetic peptide IEW (Neogen) with immunomodulating properties on postradiation recovery of haemopoiesis was investigated. We have shown that Neogen is a potential stimulator of haemopoiesis. The administration of Neogen after irradiation shortened duration of period of the recovery of the compartment of CFU-S-8 and the amount of bone marrow cells. The comparision of the effects of Neogen and GM-CSF (Leucomax) and G-CSF (Granocyte 34) have shown that the targets for these agents are probably different: polypotent CFU-S-for Neogen, and CFU-GM-for GM-CFS. Based on the results, we suggested the mechanism of Neogen effects on heamopoiesis.
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