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  • Title: Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2.
    Author: Gupta RA, Dubois RN.
    Journal: Nat Rev Cancer; 2001 Oct; 1(1):11-21. PubMed ID: 11900248.
    Abstract:
    Population-based studies have established that long-term intake of non-steroidal anti-inflammatory drugs (NSAIDs), compounds that inhibit the enzymatic activity of cyclooxygenase (COX), reduces the relative risk for developing colorectal cancer. These studies led to the identification of a molecular target, COX-2, that is involved in tumour promotion during colorectal cancer progression. Recent studies in humans indicate that therapy with specific COX-2 inhibitors might be an effective approach to colorectal cancer prevention and treatment.
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