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  • Title: Yttrium-90 citrate colloid for radioisotope synovectomy.
    Author: Bowen BM, Darracott J, Garnett ES, Tomlinson RH.
    Journal: Am J Hosp Pharm; 1975 Oct; 32(10):1027-30. PubMed ID: 1190215.
    Abstract:
    The preparation of an yttrium-90 citrate colloid is described. This formulation localizes in the synovial membrane and thereby eliminates any irradiation received by extra-articular tissues. Yttrium-90 is eluted from Sr-90 bound to a sulphonic acid ion exchange resin. The colloid is prepared using a 3:1 ratio of carrier yttrium and citrate. Contamination with ionic 90Y and ionic 90Sr was less than 1 percent and 0.001 percent, respectively. In the 28 patients studied, all of the injected dose of 90Y remained in the region of the joint. Brief clinical results are presented.
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