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  • Title: Lysine regulation of penicillin biosynthesis in low-producing and industrial strains of Penicillium chrysogenum.
    Author: Luengo JM, Revilla G, Villanueva JR, Martín JF.
    Journal: J Gen Microbiol; 1979 Nov; 115(1):207-11. PubMed ID: 119032.
    Abstract:
    The inhibitory effect of L-lysine on penicillin biosynthesis by Penicillium chrysogenum has been compared in a low-producing strain (Wis. 54-1255) and a high-producing strain (ASP-78). Lysine inhibited total penicillin synthesis to a similar extent in both strains. However, in the high-producing strain the onset of penicillin synthesis occurred even at a high lysine concentration, whereas in the low-producing strain lysine had to be depleted before penicillin production commenced.
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