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  • Title: Pharmacokinetic behavior of marbofloxacin after intravenous and intramuscular administrations in adult goats.
    Author: Waxman S, Rodríguez C, González F, De Vicente ML, San Andrés MI, San Andrés MD.
    Journal: J Vet Pharmacol Ther; 2001 Dec; 24(6):375-8. PubMed ID: 11903866.
    Abstract:
    The pharmacokinetic behavior of marbofloxacin was studied in goats after single-dose intravenous (i.v.) and intramuscular (i.m.) administrations of 2 mg/kg bodyweight. Drug concentration in plasma was determined by high performance liquid chromatography (HPLC) and the data collected were subjected to compartmental and noncompartmental kinetic analysis. This compound presented a relatively high volume of distribution (Vss=1.31 L/kg), which suggests good tissue penetration, and a total body clearance (Cl) of 0.23 L/kg small middle doth, which is related to a long elimination half-life (t1/2beta=7.18 h and 6.70 h i.v. and i.m., respectively). Pharmacokinetic parameters were not significantly different between both routes of administration. Marbofloxacin was rapidly absorbed after i.m. administration (Tmax=0.9 h) and had high bioavailability (F=100.74%).
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