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  • Title: Sequential changes of hypoxia-inducible factor 1 alpha in experimental spinal cord injury and its significance.
    Author: Ju Y, He M, Mao B.
    Journal: Chin J Traumatol; 2002 Apr; 5(2):103-6. PubMed ID: 11904072.
    Abstract:
    OBJECTIVE: To study the sequential changes of HIF-1alpha (hypoxia-inducible factor 1 alpha) in experimental spinal cord injury in rats and to analyze its potential effects in SCI. METHODS: A static compression model of SCI was employed in this study. Expressions of HIF-1alpha were measured with immunohistochemical staining, while flow cytometry was used to determine the apoptotic ratio and bcl-2 expressions. RESULTS: HIF-1alpha began to increase 1 day after injury, and reached the peak at 3-7 days. Two weeks later, it declined significantly. The sequential changes of HIF-1alpha coincided well with the alterations of apoptotic ratio and contents of bcl-2. CONCLUSIONS: HIF-1alpha possibly participates in the secondary ischemic and hypoxic procedures after spinal cord injury, and may mediate the traumatic apoptosis. Further understanding of HIF-1alpha may provide new therapeutic regimens for SCI.
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