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  • Title: [Epinephrine injection with enflurane anaesthesia: incidence of cardiac arrhythmias (author's transl)].
    Author: Lippmann M, Reisner LS.
    Journal: Anaesthesist; 1975 Oct; 24(10):437-9. PubMed ID: 1190414.
    Abstract:
    Two hundred patients, primarily A.S.A. status I and II, were prospectively divided into two groups of 100 each. One group received nitrous oxideoxygen-enflurane anaesthesia and subcutaneous infiltration of adrenaline in lignocaine for haemostasis, while the other received enflurane but not adrenalin. Patients were continuously monitored with a cardioscope. Epinephrine dosages were limited to those recommended for safe use with halothane anaesthesia. No patient in the control group experienced an arrhythmia, and only one patient in the study group developed a burst of premature ventricular contractions following adrenaline injection. The authors conclude that adrenaline may be given subcutaneously for hemostasis in patients under enflurane anaesthesia provided the safeguards established for halothane are observed.
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