These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Caspase 3 regulates phosphatidylserine externalization and phagocytosis of oxidatively stressed erythrocytes.
    Author: Mandal D, Moitra PK, Saha S, Basu J.
    Journal: FEBS Lett; 2002 Feb 27; 513(2-3):184-8. PubMed ID: 11904147.
    Abstract:
    The appearance of phosphatidylserine (PS) on the outer surface of red cells is an important signal for their uptake by macrophages. We report for the first time that procaspase 3 present in the anucleated mature human erythrocyte is activated under oxidative stress induced by t-butylhydroperoxide leading to impairment of the aminophospholipid translocase, PS externalization and increased erythrophagocytosis. This is the first report linking caspase 3 activation to inhibition of flippase activity and uptake of red cells by macrophages.
    [Abstract] [Full Text] [Related] [New Search]