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  • Title: Cysteinyl-tRNA formation and prolyl-tRNA synthetase.
    Author: Jacquin-Becker C, Ahel I, Ambrogelly A, Ruan B, Söll D, Stathopoulos C.
    Journal: FEBS Lett; 2002 Mar 06; 514(1):34-6. PubMed ID: 11904177.
    Abstract:
    Aminoacyl-tRNA (AA-tRNA) formation is a key step in protein biosynthesis. This reaction is catalyzed with remarkable accuracy by the AA-tRNA synthetases, a family of 20 evolutionarily conserved enzymes. The lack of cysteinyl-tRNA (Cys-tRNA) synthetase in some archaea gave rise to the discovery of the archaeal prolyl-tRNA (Pro-tRNA) synthetase, an enzyme capable of synthesizing Pro-tRNA and Cys-tRNA. Here we review our current knowledge of this fascinating process.
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