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  • Title: Cross-presentation in viral immunity and self-tolerance.
    Author: Heath WR, Carbone FR.
    Journal: Nat Rev Immunol; 2001 Nov; 1(2):126-34. PubMed ID: 11905820.
    Abstract:
    T lymphocytes recognize peptide antigens presented by class I and class II molecules encoded by the major histocompatibility complex (MHC). Classical antigen-presentation studies showed that MHC class I molecules present peptides derived from proteins synthesized within the cell, whereas MHC class II molecules present exogenous proteins captured from the environment. Emerging evidence indicates, however, that dendritic cells have a specialized capacity to process exogenous antigens into the MHC class I pathway. This function, known as cross-presentation, provides the immune system with an important mechanism for generating immunity to viruses and tolerance to self.
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