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  • Title: [Comparison of the antiarrhythmic effects of PGA1, PGA2, PGE1, PGE2 and PGF2 alpha on a barium chloride arrhythmia model in unanesthetized rabbits].
    Author: Mest H-J, Förster W.
    Journal: Arch Int Pharmacodyn Ther; 1975 Sep; 217(1):152-61. PubMed ID: 1190908.
    Abstract:
    Experimental studies on BaCl2 induced arrhythmias in unanaesthetized rabbits showed an antiarrhythmic effect of prostaglandins A1, A2, E1, E2 and F2a by infusions of 0,1 to 6,0 mug/kg/min over 3 min. There was a maximum antiarrhythmic effect between 50% and 80%. Ajmaline was similarly effective when given in doses 100-1000 times higher. PGA1 and PGE2 were most effective in this model; the ED50-values of the other PGs were 2-3 times higher. The mode of action of PGs is unknown; the following factors are discussed: the influence on the ionic movements, the negative feedback mechanism on the release of adrenergic transmitter and central nervous effects.
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