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  • Title: Effects of L-dopa on myocardial contractile force: a reappraisal.
    Author: Wenger JJ, Osborne MW.
    Journal: Arch Int Pharmacodyn Ther; 1975 Oct; 217(2):251-6. PubMed ID: 1190920.
    Abstract:
    The apparent decrease in myocardial force of contraction observed after L-dopa, 10 mg/kg i.v., is artifactual since the maximum rate of left venticular isovolumic pressure rise (dP/dt) remains elevated. The apparent decrease is due to shrinkage in heart size secondary to venous "pooling". The decrease in contractile force parallels a decrease in cardiac output. A peripheral decarboxylase inhibitor and L-dopa produce a decrease in both contractile force and dP/dt. Strain gauge arch recordings may produce false-positive data during marked venous pooling.
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