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  • Title: Primary leptomeningeal melanomatosis: early leptomeningeal enhancement on MRI.
    Author: Celli P, Acqui M, Trillò G, Ramundo EO, D'Andrea G, Roperto R, Ferrante L.
    Journal: J Neurosurg Sci; 2001 Dec; 45(4):235-40. PubMed ID: 11912478.
    Abstract:
    One unusual case of primary leptomeningeal melanomatosis is presented. The patient, 53-year-old male, was admitted to our observation for 1 month history of psychasthenia and amnesia. Despite several polyspecialistic clinical, neuroradiological and cytological examinations, conclusive diagnosis was made only with a biopsy of leptomeningeal nodule. The present case allows as to identify 2 stages in the evolution of primary diffuse leptomeningeal melanomatosis. The initial phase is characterized by slight mental impairment without hydrocephalus; during the later phase there is severe, diffuse neurological impairment and both CT and MRI show hypercaptation of the intracranial leptomeninges and multiple, leptomeningeal tumoral nodules.
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