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  • Title: Cyanoacrylate medical adhesives--a new era Colgate ORABASE Soothe.N.Seal Liquid Protectant for canker sore relief.
    Author: Narang U.
    Journal: Compend Contin Educ Dent Suppl; 2001; (32):7-11; quiz 22. PubMed ID: 11915641.
    Abstract:
    Cyanoacrylate, a synthetic adhesive, is a fast polymerizable liquid monomer. Serendipity led to the discovery of cyanoacrylate adhesives in 1951. Today, a specific cyanoacrylate monomer, 2-octyl cyanoacrylate, is being used in a topical medical adhesive formulation. The only over-the-counter cyanoacrylate-based product cleared by the Food and Drug Administration is Colgate ORABASE Soothe.N. Seal Liquid Protectant. Upon application, this liquid monomer formulation polymerizes instantly into a thin, flexible polymer film that adheres tenaciously to mucosal tissue. This polymer film creates a mechanical barrier that provides immediate and long-term pain relief of oral ulcerations and irritations, and maintains a natural healing environment for the area to heal.
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