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  • Title: Effects of vincristine on normal and stimulated megakaryocytopoiesis in the rat.
    Author: Ebbe S, Howard D, Phalen E, Stohlman F.
    Journal: Br J Haematol; 1975 Apr; 29(4):593-603. PubMed ID: 1191566.
    Abstract:
    Vincristine was given to rats in which thrombocytopoiesis was either normal or acutely or chronically stimulated by injections of heterologous antiplatelet serum. A single dose of 0.3 mg/kg was given intravenously. The drug produced an early and a delayed megakaryocytopenia suggesting that it was toxic to differentiated megakaryocytes as well as to proliferating stem cells. The results support the hypothesis that vincristine-induced thrombocytosis may be due to homeostatic adjustments which, in turn, are activated as a result of drug-induced cytotoxicity.
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