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  • Title: Skeletal muscle fatty acid transport and transporters.
    Author: Luiken JJ, Miskovic D, Arumugam Y, Glatz JF, Bonen A.
    Journal: Int J Sport Nutr Exerc Metab; 2001 Dec; 11 Suppl():S92-6. PubMed ID: 11915935.
    Abstract:
    While it has long been assumed that long chain fatty acids (LCFA) can freely diffuse across the plasma membrane, recent work has shown that LCFA uptake also involves a protein-mediated mechanism. Three putative LCFA transporters have been identified (FABPpm, FATP, and FAT/CD36), and all are expressed in rodent and human muscles. In a new model system (giant vesicles), we have demonstrated that (a) LCFA transport rates are scaled with the oxidative capacity of heart and muscle, (b) only FABPpm and FAT/CD36, but not FATP1, correlate with vesicular LCFA transport, and (c) LCFA transport can be increased by increasing (1) the FAT/CD36 protein of muscle (chronic adaptation) or (2) via the translocation of FAT/CD36 from an intracellular pool to the plasma membrane during muscle contraction (acute adaptation).
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