These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Electrophysiologic parameters and predisposing factors in the generation of drug-induced Torsade de Pointes arrhythmias.
    Author: Vos MA, van Opstal JM, Leunissen JD, Verduyn SC.
    Journal: Pharmacol Ther; 2001; 92(2-3):109-22. PubMed ID: 11916532.
    Abstract:
    When a new (cardiovascular) drug shows signs of QT interval prolongation on the ECG (delay in repolarization time), the regulatory agencies demand screening of its possible proarrhythmic potential before approving it for clinical practice. In this review, identified predisposing factors have been related to specific electrophysiological parameters, allowing quantification of their contribution to Torsade de Pointes arrhythmias. In addition, arrhythmogenic mechanisms involved in the initiation and perpetuation of drug-induced Torsade de Pointes are discussed.
    [Abstract] [Full Text] [Related] [New Search]