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  • Title: [Effect of reversible inhibitors on the thermal denaturation of cholinesterases].
    Author: Tonkopiĭ VD, Padinker EB.
    Journal: Biull Eksp Biol Med; 1975 Apr; 79(4):51-2. PubMed ID: 1191768.
    Abstract:
    The capacity of reversible inhibitors--galanthamine and tacrine--to protect the cholinesterase of rat and mouse brain from the thermal denaturation with the action of the temperature of 56 and 58 degrees C was revealed. The protective action was also noted when the reversible inhibitors decreased the activity of the enzyme. It appeared that with galanthamine the cholinesterase resistance to the thermal action was greater than with the action of tacrine.
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