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  • Title: Allogeneic blood stem cell transplantation following non-myeloablative conditioning for hypereosinophilic syndrome.
    Author: Juvonen E, Volin L, Koponen A, Ruutu T.
    Journal: Bone Marrow Transplant; 2002 Mar; 29(5):457-8. PubMed ID: 11919738.
    Abstract:
    A male patient with hypereosinophilic syndrome (HES) underwent an allogeneic blood stem cell transplantation from a female donor following non-myeloablative conditioning consisting of a 2 Gy dose of TBI and fludarabine 30 mg/m(2) intravenously on three days. Before transplantation 100% of the mitotic bone marrow cells of the patient showed a clonal karyotype abnormality. Three months after the transplantation eosinophilia had resolved and a chromosome analysis revealed normal female karyotype. The present study shows that stem cell transplantation after non-myeloablative conditioning may have curative potential for HES.
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