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  • Title: Simultaneous determination of ondansetron and tropisetron in human plasma using HPLC with UV detection.
    Author: Bauer S, Störmer E, Kaiser R, Tremblay PB, Brockmöller J, Roots I.
    Journal: Biomed Chromatogr; 2002 May; 16(3):187-90. PubMed ID: 11920943.
    Abstract:
    A rapid and sensitive HPLC method for the simultaneous quantitation of ondansetron and tropisetron, two serotonin (5-HT) receptor antagonists frequently used in treatment and prevention of nausea and emesis, is described. The procedure involves liquid-liquid extraction of human plasma with dichloromethane coupled with reversed-phase HPLC and UV detection. The lower limits of quantification (LOQ) were 0.62 ng/mL for ondansetron and 1.25 ng/mL or tropisetron. Intra- and inter-assay coefficients of variation ranged from 1.5 to 7.5% and 5.3 to 13.7%, respectively. The sensitivity and precision were sufficient for determination of plasma concentrations after therapeutic administration of both drugs and the method can be used for the estimation of pharmacokinetic parameters.
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