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  • Title: [Circadian and ultradian cycles in narcolepsy].
    Author: Espa F, Besset A.
    Journal: Rev Neurol (Paris); 2001 Nov; 157(11 Pt 2):S87-91. PubMed ID: 11924048.
    Abstract:
    In narcolepsy, homeostatic process is preserved while sleep/wake circadian process is impaired. Other circadian components (body temperature, endocrine secretions, subjective sleepiness) are preserved. This circadian system weakness permits the occurrence of a very strong ultradian component, modulating sleep/wake rhythm. So, a 4 hour ultradian rhythmicity of Slow Wave Activity, and a 2 hour NREM/REM cycle longer than in normal subjects, has been evidenced in narcoleptic patients. These circadian and ultradian alterations can explain a major part of the narcoleptic symptoms.
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