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  • Title: [Chordoma: atypical mediastinal mass. Report of a case].
    Author: Mahassini N, Bernoussi Z, Toubi F, Harmouch A, Bourkadi JE, Mansouri F, el Hachimi A.
    Journal: Rev Pneumol Clin; 2001 Dec; 57(6):427-30. PubMed ID: 11924152.
    Abstract:
    Chordoma is a rare tumor which develops from remnant notochord tissue. Sacro-coccygeal and spheno-occipital localizations predominate. We report a thoracic chordoma of the fifth thoracic vertebra with mediastinal expansion in a 70-year-old woman. Pathology confirmed the diagnosis revealing a lobulated architecture, presence of physaliphorous cells and intracellular mucoid substance. Immunohistochemistry can also be very helpful in atypical cases: positive for anti-cytokeratine, antivimetin and anti-protein S100 antibodies. Spontaneous outcome is fatal. Early and complete resection is the only way to improve prognosis.
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