These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Screening for the new variant of defective receptor-binding apolipoprotein B-100].
    Author: Li Y, Feng J, Li W.
    Journal: Zhonghua Yi Xue Za Zhi; 2001 Dec 10; 81(23):1434-5. PubMed ID: 11930615.
    Abstract:
    OBJECTIVE: To detect possibly existing unknown mutation(s) in nucleotide sequence coding amino acid residues 2,980 to 3,084, that may lead to familial defective apo B-100, and to provide evidence for evaluating the putative receptor binding domain of apo B-100. METHODS: The nucleotide sequence coding the amino acid resudues 2,980-3,084 of apo B gene in 341 patients with primary hypercholesteremia and of 50 controls was amplified by PCR and subjected to single strand conformational polymorphism analysis under optimized conditions. RESULTS: No abnormal electrophoretic figure was found in the samples from 341 hypercholesterlemic patients and 50 controls. CONCLUSION: (1) Point mutation causing hypercholesterlemia is unlikely to exist, or rare, if any, in the codons 2,980-3,084 of apo B-100 in Chinese. (2) Amino acid residues 2,980-3,084 may not be involved in the receptor-binding of apo B-100.
    [Abstract] [Full Text] [Related] [New Search]