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  • Title: [Relationship between expression of inducible nitric oxide synthase and of VEGF in oral carcinoma].
    Author: Zhao S, Liu Y, Ping F.
    Journal: Zhonghua Kou Qiang Yi Xue Za Zhi; 2001 Nov; 36(6):461-3. PubMed ID: 11930727.
    Abstract:
    OBJECTIVE: To study the expression of inducible NOS in oral carcinoma and it's relationship with the expression of VEGF, MVD and lymphatic metastasis. METHODS: With 9 cases of normal oral mucosa as control, the expression of iNOS in 41 cases of oral carcinoma was evaluated by immunohistochemistry SP staining. Meanwhile MVD and the expression of VEGF were also detected. RESULTS: The expression rate of iNOS in 41 cases was 63.41%, and the rate between N+ group and N- group was significantly different (P < 0.01). There were significant difference of MVD (P < 0.001) and of the expression of VEGF(P < 0.05) among groups of different iNOS expression level. CONCLUSIONS: The expression of iNOS in oral carcinomas is high, and it is closely related to angiogenesis and lymphatic metastasis. The expression of iNOS probably takes part in VEGF's angiogenic effect.
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