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  • Title: [Prognostic significance of heat shock proteins 70 and p27 protein in patients with mucoepidermoid carcinoma].
    Author: Zhang Z, Zhang Y, Liu J.
    Journal: Zhonghua Kou Qiang Yi Xue Za Zhi; 2001 Nov; 36(6):467-70. PubMed ID: 11930729.
    Abstract:
    OBJECTIVE: To study the expression of heat shock proteins 70 (HSP70) and p27 in mucoepidermoid carcinoma (MEC) in relation to biological behaviour and prognosis. METHODS: Immunohistochemical LSAB method was used to evaluate the expression of HSP70 and p27 in 44 MEC. 10 Pleomorphic adenomas (PAs) were used as controls. RESULTS: The expression of HSP70 was significantly higher in MEC than in PAs, while p27 expression was significantly lower in MEC than in PAs. There was a negative correlation between HSP70 and p27 expression. Compared with clinicopathologic features, the expression of HSP70 was related to histologic grade, clinical stage and tumor size, and p27 expression correlated negatively with histologic grade, clinical stage, tumor size and lymph node metastases. Multivariate analysis revealed that Hsp70 expression was a strong prognostic indicator of MEC. CONCLUSIONS: HSP70 should be considered an independent prognostic indicator of MEC and p27 might favour prognosis of MEC.
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