These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Studies on catabolism of 125I-labelled fibrinogen in normal rabbits and in rabbits with indwelling intravenous catheters: methodologic aspects.
    Author: Mahn I, Müller-Berghaus G.
    Journal: Haemostasis; 1975; 4(1):41-50. PubMed ID: 1193455.
    Abstract:
    The catabolism of rabbit fibrinogen labelled with radioactive iodine was studied over a period of 7-9 days in normal rabbits and in rabbits with indwelling intravenous catheters. The labelled fibrinogen was highly clottable and homogeneous on immunoelectrophoresis and disc electrophoresis. The protein-bound 125I-activity amounted to at least 99%. Normal rabbits with a weight between 1.6 and 2.2 kg exhibited a mean plasma volume of 41.65 ml/kg. A mean half-life time of 1.69 days and a mean fractional catabolic rate of 59.8% of the plasma fibrinogen pool per day was computed by tracing labelled fibrinogen. The absolute catabolic rate revealed a mean value of 58.7 mg/kg body weight/day. Comparable results were obtained for all three labelled fibrinogen batches. A siliconized polyvinyl tubing with an outer diameter of 2.0 mm inserted into a jugular vein up to a length of 10-12 cm and indwelling for more than 10 days did not significantly influence the parameters studied for controlling the fibrinogen catabolism except for the absolute catabolic rate of 112.8 mg/kg/day which differed significantly from that of the control group. Thus, the indwelling intravenous catheter had no or only a minor effect on the activation of intravascular coagulation.
    [Abstract] [Full Text] [Related] [New Search]