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  • Title: Relationship between sleep and secretion of gonadotropin and ovarian hormones in women with normal cycles.
    Author: Touzet S, Rabilloud M, Boehringer H, Barranco E, Ecochard R.
    Journal: Fertil Steril; 2002 Apr; 77(4):738-44. PubMed ID: 11937126.
    Abstract:
    OBJECTIVE: To monitor gonadotropin and ovarian hormone levels in relation to sleep duration in normally cycling women. DESIGN: Observational and cross-sectional study. SETTING: Multicentric collaborative study. PATIENT(S): One hundred six healthy and normally cycling women, aged 19 to 44 years, with cycle lengths of 24 to 34 days. INTERVENTION(S): Follow-up during one to four consecutive cycles with daily urine collection. MAIN OUTCOME MEASURE(S): Urine concentrations of LH, FSH, estrone-3-glucuronide (E1-3-G), and pregnanediol-3-alpha-glucuronide (Pd-3alpha-G). Ultrasound determination of day of ovulation and estimation of sleep duration. RESULT(S): We found a significant association between FSH levels and sleep duration (P=.008). Follicle-stimulating hormone levels were 20% higher in long-time sleepers than in short-time sleepers. This association persisted whatever the age or the body mass index. There was no significant association between belonging to any group and LH, E1-3-G, or Pd-3alpha-G levels. CONCLUSION(S): Our results suggest that sleep duration could be related to FSH levels, although the study design did not allow us to establish a causal relationship nor to explain the physiological basis of the observed relationship.
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