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  • Title: Precocious puberty in a female with Proteus Syndrome.
    Author: Ezzeldin KM, Ezzeldin AA, Zahrani AJ, Al-Zaiem MM.
    Journal: Saudi Med J; 2002 Mar; 23(3):332-4. PubMed ID: 11938428.
    Abstract:
    Proteus syndrome is a complex disorder comprising malformations and overgrowth of multiple tissues and characterized by its polymorphism and mosaicism. The syndrome is rare and sporadic. Oliveira M da C et al reported the first case of Proteus syndrome associated with precocious puberty in a boy. We are reporting a case of a 7-month old girl with Proteus syndrome who developed a juvenile granulosa cell tumor in one ovary causing precocious puberty. At our knowledge this is the first case of Proteus syndrome with precocious puberty in a female.
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