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  • Title: [Heritability of serum leptin levels: a twin study].
    Author: Wu M, He Q, Zhu D, He X, Wang G, Gao P, Zhou H, Zhang W, Zhao G.
    Journal: Zhonghua Yi Xue Yi Chuan Xue Za Zhi; 2002 Apr; 19(2):112-4. PubMed ID: 11941584.
    Abstract:
    OBJECTIVE: To study the contribution of genetic factors to the variance of serum leptin concentration in healthy, normotensive twins. METHODS: A total of 57 pairs of twins were investigated: 28 female and 19 male pairs of monozygotic(MZ) twins, and 6 female and 4 male pairs of dizygotic(DZ) twins. The zygosity of twins was determined by comparing the concordance of the genotype of nine fluorescence-labeled microsatellite markers. The genetic analysis was performed using the variance-based method. Serum leptin levels were determined in duplicate by a radioimmunoassay Kit (Linco Research, Inc., St. Charles, Missouri) as previously described. RESULTS: The test of genetic variance revealed a significantly larger within-pair variance of serum leptin in the DZ twins, in comparison with the MZ twins. The corresponding heritability for serum leptin was 8%. Adjusted for BMI, gender, and uric acid (UA), the heritability for serum leptin was 0.18%. Log leptin correlated significantly with blood pressure (SBp r=0.355 P<0.001; DBp r=0.339 P<0.001). Stepwise multiple linear regression analysis revealed that only BMI, gender and UA were linked independently to serum leptin levels(R(2)=0.788, P<0.001). CONCLUSION: The above data indicate that environmental factors other than genetic factors are important determinants of leptinemia in normal subjects.
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