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  • Title: Mechanisms of cross-talk between G-protein-coupled receptors.
    Author: Cordeaux Y, Hill SJ.
    Journal: Neurosignals; 2002; 11(1):45-57. PubMed ID: 11943882.
    Abstract:
    There is increasing evidence to suggest that 'cross-talk' occurs between G-protein-coupled receptors and their intracellular second messenger pathways. Cross-talk between different pathways may occur at the level of receptors, G-proteins, effectors or second messengers and may serve to fine-tune cell signalling. There is a growing body of evidence to suggest that cellular compartmentalization may play a crucial role in regulating these cross-talk interactions. Understanding the mechanisms of cross-talk may therefore be the key to the design and application of future therapeutics and the development of drug specificity.
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