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  • Title: L-Methionine-gamma-lyase, as a target to inhibit malodorous bacterial growth by trifluoromethionine.
    Author: Yoshimura M, Nakano Y, Koga T.
    Journal: Biochem Biophys Res Commun; 2002 Apr 12; 292(4):964-8. PubMed ID: 11944909.
    Abstract:
    Methyl mercaptan is a major component responsible for oral malodor. This compound arises from the bacterial metabolism of methionine. Here we show that the growth of Porphyromonas gingivalis, a periodontal microorganism that produces large amounts of methyl mercaptan, was strongly inhibited by l-trifluoromethionine (TFM), a fluorinated derivative of methionine. In contrast, TFM had no effect on the growth of bacteria which do not produce methyl mercaptan. In addition, the survival rate of P. gingivalis-infected mice was remarkably increased by the co-injection of TFM. These results suggest that TFM is a promising antibacterial agent specific to the malodorous oral bacteria.
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