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  • Title: Arylpiperazine derivatives acting at 5-HT(1A) receptors.
    Author: López-Rodríguez ML, Ayala D, Benhamú B, Morcillo MJ, Viso A.
    Journal: Curr Med Chem; 2002 Feb; 9(4):443-69. PubMed ID: 11945120.
    Abstract:
    Serotonin (5-hydroxytryptamine, 5-HT) is one of the most attractive targets for medicinal chemists. Among 5-HTRs, the 5-HT(1A) subtype is the best studied and it is generally accepted that it is involved in psychiatric disorders such as anxiety and depression. Several structurally different compounds are known to bind 5-HT(1A)R sites. Among these, arylpiperazine derivatives represent one of the most important classes of 5-HT(1A)R ligands. This article will review the development of arylpiperazine derivatives acting at 5-HT(1A)Rs with an emphasis on structure-affinity relationships of agonists and antagonists, ligand-receptor interactions and pharmacological applications.
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