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  • Title: Changes in plasma concentrations of luteinizing hormone after injection of progesterone at various times during the ovulatory cycle of the domestic hen (Gallus domesticus).
    Author: Wilson SC, Sharp PJ.
    Journal: J Endocrinol; 1975 Oct; 67(1):59-70. PubMed ID: 1194828.
    Abstract:
    Changes in plasma LH concentrations after i.m. injections of 0-5 mg progesterone/kg at various stages of the ovulatory cycle were measured by radioimmunoassay. Four types of response were observed. (1) When the steroid was injected between 4 h after and 12 h before an ovulation, LH levels started to rise after 15--45 min and reached peak values within 90--120 min. The mean maximal incremental change in the level of LH was 1-58 +/- 0-10(S.E.M.) ng/ml (n = 37). (2) In contrast, when progesterone was injected 12--8 h before ovulation, i.e. immediately before a spontaneous pre-ovulatory LH surge, the resulting mean maximal incremental change in LH level, 0-79 +/- 0-12 ng/ml (n = 9), was significantly smaller (P less than 0-001). (3) If progesterone was injected 8--4 h before ovulation, i.e. when pre-ovulatory LH levels were rising, they immediately started to rise more rapidly and reached peak values within 45 min. The maximal incremental change in the level of LH under these circumstances, 2-34 +/- 0-20 ng/ml (n = 12), was significantly greater (P less than 0-001) in both cases) than the changes observed in the responses 1 and 2 described above. (4) Levels of LH generally showed no incremental change in response to injections of progesterone given 4--0 h before ovulation, i.e. when pre-ovulatory LH levels were falling. It was concluded that the type of change in plasma LH levels induced by progesterone depended upon the stage of the ovulatory cycle at which the steroid was injected.
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